Low Testosterone and Heart Disease. What You Need to Know

Heart, Pulse, Health, Cardiac, MedicineTestosterone (Te), is an important hormone which decreases naturally as men age. Low Te levels can cause decreased libido, decreased bone mineral density, depression, fatigue, erectile dysfunction, and reduced muscle strength/mass (Kloner et. al., 2016). Testosterone supplementation has been shown to improve mood and energy levels and is thought to give athletes a competitive advantage by increasing muscle strength and mental focus (Tokish & DeRosa, 2016).

Cardiovascular disease is the leading cause of death for men and women globally (Tambo, Roshan, & Pace, 2016). There are many risk factors of cardiovascular disease such as family history, age, gender, blood pressure, cholesterol, blood sugar, obesity, smoking, and exercise (Harvard Health, 2010). Low Te has also been shown to be a risk factor for cardiovascular disease and testosterone replacement therapy (TRT) can have positive, protective effects on the cardiac system (Kloner et. al., 2016) by decreasing obesity, dilating blood vessels in the heart, and decreases the risk of diabetes (Harvard Health, 2010).

TRT remains controversial in men who have known cardiovascular disease although there have been no studies showing a statistically significant link between TRT and a cardiovascular adverse event such as a stroke or heart attack (Tambo, Rashan, & Pace, 2016). Testosterone replacement has been shown to be beneficial for both athletic performance and protecting the heart from disease. Contact Dr. Dave Carfagno at (480) 664- 4615 to learn if TRT is right for you.


Harvard Health Publishing. (2010). Testosterone and the heart. Retrieved from https://www.health.harvard.edu/heart-health/testosterone-and-the-heart

Kloner, R. A., Carson, C., Dobs, A., Kopecky, S., & Mohler, E. R. (2016). Testosterone and cardiovascular disease. Journal of the American College of Cardiology, 67(5) 545-557. https://doi.org/10.1016/j.jacc.2015.12.005

Tambo, A., Roshan, M. H. K., & Pace, N. P. (2016). Testosterone and cardiovascular disease. The Open Cardiovascular Medicine Journal, 10, 1–10. http://doi.org/10.2174/1874192401610010001

Tokish, J. M., & DeRosa, D. C. (2014). Pharmacologic Approaches to the Aging Athlete. Sports Health, 6(1), 49–55. http://doi.org/10.1177/1941738113512782